Development of an Innovative Nanosystem Based on Functionalized Albumin and Oxidized Gellan for the Synergistic Delivery of Curcumin and Temozolomide in the Treatment of Brain Cancer

Treating brain cancer remains challenging due to the blood–brain barrier (BBB) and the systemic toxicity of chemotherapy. This study focuses on developing human serum albumin (HSA) nanoparticles modified with low-molecular-weight protamine (LMWP) to improve crossing the BBB and enable targeted deliv...

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Bibliografische gegevens
Hoofdauteurs: Camelia Elena Iurciuc (Tincu), Gabriela Vochița, Daniela Gherghel, Cosmin-Teodor Mihai, Silvia Vasiliu, Ștefania Racoviță, Anca Niculina Cadinoiu, Corina Lenuța Logigan, Mihaela Hamcerencu, Florin Mitu, Marcel Popa, Lăcrămioara Ochiuz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2025-09-01
Reeks:Gels
Onderwerpen:
functionalization of human serum albumin
HSA-based nanoparticles
overcoming blood–brain barrier
oxidized gellan crosslinking
target delivery
synergic effect of co-encapsulated curcumin and temozolomide
Online toegang:https://www.mdpi.com/2310-2861/11/9/708
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