Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.

書目詳細資料

Principais autores:	Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B. Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2018-01-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-017-01859-9
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