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Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2

Duck hepatitis A virus type 1 (DHAV-1) is one of the most deadly pathogens that endanger the duck industry. Most viruses usually turn off host translation after infection to facilitate viral replication and translation. For the first time report to our knowledge, DHAV-1 can induce eIF2α phosphorylat...

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Principais autores: Yuanzhi Liu, Anchun Cheng, Mingshu Wang, Sai Mao, Xumin Ou, Qiao Yang, Ying Wu, Qun Gao, Mafeng Liu, Shaqiu Zhang, Juan Huang, Renyong Jia, Dekang Zhu, Shun Chen, Xinxin Zhao, Yanling Yu, Yunya Liu, Ling Zhang, Bin Tian, Leichang Pan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Microbiology
Fag:
duck hepatitis A virus type 1
eIF2α
PERK
GCN2
translation shutoff
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2021.624540/full
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