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Application Route and Immune Status of the Host Determine Safety and Oncolytic Activity of Oncolytic Coxsackievirus B3 Variant PD-H

The coxsackievirus B3 strain PD-0 has been proposed as a new oncolytic virus for the treatment of colorectal carcinoma. Here, we generated a cDNA clone of PD-0 and analyzed the virus PD-H, newly generated from this cDNA, in xenografted and syngenic models of colorectal cancer. Replication and cytoto...

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Detalles Bibliográficos
Principais autores: Ahmet Hazini, Babette Dieringer, Karin Klingel, Markian Pryshliak, Anja Geisler, Dennis Kobelt, Ole Daberkow, Jens Kurreck, Sophie van Linthout, Henry Fechner
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-09-01
Series:Viruses
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Acceso en liña:https://www.mdpi.com/1999-4915/13/10/1918
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