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Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells

Calcitriol, a vitamin D<sub>3</sub> metabolite, is approved for various indications because it is the bioactive form of vitamin D in the body. The purpose of this study was to predict the clinical significance of cytochrome P450 (CYP) induction by calcitriol using in vitro human cryopreserved hepato...

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Furkejuvvon:
Váldodahkkit: Yoon-Jee Chae, Min-Soo Kim, Suk-Jae Chung, Mi-Kyung Lee, Kyeong-Ryoon Lee, Han-Joo Maeng
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2021-01-01
Ráidu:Pharmaceutics
Fáttát:
calcitriol
CYP induction
human cryopreserved hepatocytes
HepaRG
basic model
static mechanistic model
Liŋkkat:https://www.mdpi.com/1999-4923/13/2/181
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