Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa

Background The role of plasma and its components in the progression of aortic stenosis (AS) remains insufficiently investigated. This study aimed to assess whether plasma from patients with AS induces oxidative stress and contributes to valvular endothelial cells (VECs) dysfunction. Methods Human pl...

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Principais autores:	Antonin Trimaille, Sandy Hmadeh, Shinnosuke Kikuchi, Ali Mroueh, Adrien Carmona, Benjamin Marchandot, Francis Beras, Dinh Phi Truong, Manh Cuong Vu, Amandine Granier, Laurence Jesel, Patrick Ohlmann, Laurent Sattler, Valérie Schini‐Kerth, Olivier Morel
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-03-01
Series:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	aortic stenosis endothelial dysfunction inflammation SGLT2 inhibitors thrombosis
Acceso en liña:	https://www.ahajournals.org/doi/10.1161/JAHA.125.041701
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