Large-scale generation of IL-12 secreting macrophages from human pluripotent stem cells for cancer therapy

Genetically engineered macrophages (GEMs) have emerged as an appealing strategy to treat cancers, but they are largely impeded by the cell availability and technical challenges in gene transfer. Here, we develop an efficient approach to generate large-scale macrophages from human induced pluripotent...

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Detalhes bibliográficos

Principais autores:	Baoqiang Kang, Qi Xing, Yuhua Huang, Huaisong Lin, Jiaojiao Peng, Zhishuai Zhang, Mingquan Wang, Xinrui Guo, Xing Hu, Shuoting Wang, Junwei Wang, Minghui Gao, Yanling Zhu, Guangjin Pan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-03-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	macrophage iPSCs differentiation CRISPR-Cas9 IL-12 cancer immunotherapy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050124000202
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