Antitumor Effects of PD-1 Blockade Combined with Mild Hyperthermia in a Murine Osteosarcoma Model

<b>Background</b>: Osteosarcoma remains largely refractory to immune checkpoint inhibitor (ICI) monotherapy, and strategies to modulate the tumor immune microenvironment are being actively explored. Mild hyperthermia has been reported to influence antitumor immune responses; however, its impact in c...

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Auteurs principaux:	Yuya Izubuchi, Naoi Hosoe, Takaaki Tanaka, Yumiko Watanabe, Tatsunobu Kobayashi, Hideaki Nakajima, Hiroyasu Kidoya, Akihiko Matsumine
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2026-02-01
Collection:	Biomedicines
Sujets:	osteosarcoma immunotherapy PD-1 blockade hyperthermia T cell macrophage
Accès en ligne:	https://www.mdpi.com/2227-9059/14/2/341
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