Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

The human proteome is replete with short linear motifs (SLiMs) of four to six residues that are critical for protein-protein interactions, yet the importance of the sequence surrounding such motifs is underexplored. We devised a proteomic screen to examine the influence of SLiM sequence context on p...

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Autori principali:	Theresa Hwang, Sara S Parker, Samantha M Hill, Robert A Grant, Meucci W Ilunga, Venkatesh Sivaraman, Ghassan Mouneimne, Amy E Keating
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2022-01-01
Serie:	eLife
Soggetti:	short linear motif actin ena/vasp EVH1 protein-protein interaction
Accesso online:	https://elifesciences.org/articles/70680
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