Point Mutations in the FLT3-ITD Region Are Rare but Recurrent Alterations in Adult AML and Associated With Concomitant KMT2A-PTD

FLT3-ITD mutations are common druggable alterations in patients with acute myeloid leukemia (AML) and associated with poor prognosis. Beside typical ITD mutations, point mutations and deletions in the juxtamembrane domain (JMD) have been observed. However, due to the low frequency of these alteratio...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Sebastian Stasik, Michael Kramer, Sven Zukunft, Christoph Röllig, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Carsten Müller-Tidow, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan Krause, Tim Sauer, Mathias Hänel, Andreas Neubauer, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Christian Thiede
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2022-03-01
سلاسل:	Frontiers in Oncology
الموضوعات:	FLT3-ITD point mutations acute myeloid leukemia (AML) clinical outcome KMT2A-PTD
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fonc.2022.862991/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!