Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recent years, other posttranslational modifications (PTMs) have been highlighted...

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Principais autores:	François-Xavier Cantrelle, Anne Loyens, Xavier Trivelli, Oliver Reimann, Clément Despres, Neha S. Gandhi, Christian P. R. Hackenberger, Isabelle Landrieu, Caroline Smet-Nocca
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-06-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	Alzheimer’s disease microtubule-associated protein tau phosphorylation O-GlcNAc glycosylation protein aggregation NMR spectroscopy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnmol.2021.661368/full
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