GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

Abstract Background Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dysfunctional cell states fou...

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Autori principali:	Anuja Sathe, Carlos Ayala, Xiangqi Bai, Susan M. Grimes, Byrne Lee, Cindy Kin, Andrew Shelton, George Poultsides, Hanlee P. Ji
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-11-01
Serie:	Genome Medicine
Soggetti:	GITR TIGIT Tumor microenvironment scRNA-seq Gastric cancer Colon cancer
Accesso online:	https://doi.org/10.1186/s13073-023-01259-3
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