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Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.

Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to lysosomes, but the molecular mechanisms that allow Mtb to elude lysosomal degradation are poorly understood. Speciali...

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Principais autores: Alka Mehra, Aleena Zahra, Victor Thompson, Natalie Sirisaengtaksin, Ashley Wells, Maura Porto, Stefan Köster, Kristen Penberthy, Yoshihisha Kubota, Amelie Dricot, Daniel Rogan, Marc Vidal, David E Hill, Andrew J Bean, Jennifer A Philips
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-10-01
Serier:PLoS Pathogens
Online adgang:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204276/pdf/?tool=EBI
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