Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway

Abstract Background NADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity of the blood-retinal barrier. Abnormalities in neurovascular-coupled immune signaling herald the loss of ganglion cells in glaucoma. Persisten...

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Autori principali:	Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li, Verena Prokosch
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-04-01
Serie:	Journal of Neuroinflammation
Soggetti:	NADPH oxidase 2 Deletion Pharmacological inhibition Oxidative stress Neurodegeneration Neuroinflammation
Accesso online:	https://doi.org/10.1186/s12974-024-03075-x
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