AMPK/mTORC2/AKT-473/RUNX2 signaling axis modulates epithelial-mesenchymal transition and bone tropism in breast cancer
IntroductionMetformin, a widely used biguanide for the treatment of type 2 diabetes, has been extensively studied for its potential anti-cancer properties, primarily attributed to its inhibitory effects on mTORC1 signaling. However, accumulating evidence suggests that its impact on tumor progression...
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| Huvudupphov: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
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Frontiers Media S.A.
2026-04-01
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| Serie: | Frontiers in Oncology |
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| Länkar: | https://www.frontiersin.org/articles/10.3389/fonc.2026.1785903/full |
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