Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

Abstract Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, a...

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Principais autores:	Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-02-01
Serija:	Journal of Neuroinflammation
Teme:	Methamphetamine Dynorphin κ-opioid receptor Microglia Neurokinin 1 receptor
Online dostop:	http://link.springer.com/article/10.1186/s12974-018-1087-7
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