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Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD

IntroductionDual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is associated with the pathoprogression of neurodevelopmental and neurodegenerative disorders. However, the effects of direct genetic manipulation of DYRK1A in the brain on cognitive function, neuroinflammation and Al...

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Principais autores: Hyun-ju Lee, Sora Kang, Yoo Jin Lee, Seokjun Oh, Bitna Joo, Jeong-Woo Hwang, Jeongseop Kim, Tae-Eun Kim, Tae-Mi Jung, Yu-Jin Kim, Ji-Yeong Jang, Jeong-Heon Song, Ja Wook Koo, Hyang-Sook Hoe
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2025-11-01
סדרה:Frontiers in Immunology
נושאים:
DYRK1A
neuroinflammation
amyloid beta
tauopathy
cognitive function
Alzheimer’s disease
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1661791/full
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