From lactate to lactylation: novel pathological mechanisms and potential therapeutic targets for high-altitude cerebral oedema

Abstract Background High altitude cerebral edema (HACE), a fatal terminal stage of acute mountain sickness (AMS), is triggered by rapid exposure to hypoxia at high altitudes. The pathophysiology of HACE is complex, involving multiple key processes including energy metabolism disorders, oxidative str...

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Autores principales:	Chaoyi Duan, Siyu Li, Likun Yao, Xinjie Zhang, Yansheng Ding, BiWen Peng
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cambridge University Press 2026-01-01
Colección:	Expert Reviews in Molecular Medicine
Materias:	high-altitude cerebral oedema lactate lactylation neuroinflammation
Acceso en línea:	https://www.cambridge.org/core/product/identifier/S1462399426100465/type/journal_article
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