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USP22 knockdown attenuates P. gingivalis-induced EndoMT and CNS inflammation: a link between periodontitis and neuroinflammation

ObjectiveChronic periodontitis is a significant risk factor for systemic disorders. However, the precise mechanism through which the “oral-brain axis” mediates its impact on the central nervous system remains unclear. This study aimed to investigate whether the periodontal pathogen Porphyromonas gin...

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Hlavní autoři: Hui Wang, Mengxian Wang, Jiaming Shen, Hao Zhang, Chengwei Duan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-03-01
Edice:Frontiers in Neuroscience
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fnins.2026.1790970/full
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