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Structural basis of adenylyl cyclase 9 activation

Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes, AC9.

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Autori principali: Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-02-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-28685-y
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