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Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation

This study aimed to present findings on a paclitaxel (PTX)-loaded polymeric micellar formulation based on polycaprolactone-vitamin E TPGS (PCL-TPGS) and evaluate its in vitro anticancer activity as well as its in vivo pharmacokinetic profile in healthy mice in comparison to a marketed formulation. M...

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Principais autores: Ziyad Binkhathlan, Osman Yusuf, Raisuddin Ali, Abdullah H. Alomrani, Aws Alshamsan, Abdullah K. Alshememry, Aliyah Almomen, Musaed Alkholief, Ibrahim A. Aljuffali, Faleh Alqahtani, Saad Alobid, Essam A. Ali, Afsaneh Lavasanifar
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-06-01
Series:International Journal of Pharmaceutics: X
Assuntos:
Block copolymers
Polymeric micelles
Paclitaxel
Stability
In vitro cytotoxicity
Pharmacokinetics
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2590156724000252
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