Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin

Cytolethal distending toxin (CDT), a genotoxin produced by Campylobacter jejuni, is composed of three subunits: CdtA, CdtB, and CdtC. CdtB is a DNase that causes DNA double-strand breaks (DSB) in the nucleus resulting in cell cycle arrest at the G2/M stage and apoptosis. CdtA and CdtC bind to choles...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Cheng-Kuo eLai, Yu-An eChen, Chun-Jung eLin, Hwai-Jeng eLin, Min-Chuan eKao, Mei-Zi eHuang, Yu-Hsin eLin, Chuan eChiang-Ni, Chih-Jung eChen, U-Ging eLo, Li-Chiung eLin, Ho eLin, Jer-Tsong eHsieh, Chih-Ho eLai
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2016-02-01
Schriftenreihe:	Frontiers in Cellular and Infection Microbiology
Schlagworte:	Campylobacter jejuni Cholesterol trafficking cytolethal distending toxin Enzymatic activity
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00009/full
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