Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

Abstract While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in cardiomyocytes, mitochondrial isocitrate dehydrogen...

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Detalhes bibliográficos

Principais autores:	Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I. Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-46384-8
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