Chimeric immune checkpoint protein vaccines inhibit the tumorigenesis and growth of rat cholangiocarcinoma

Cholangiocarcinoma (CCA) is the second most common primary liver malignancy and carries a dismal prognosis due to difficulties in achieving an optimal resection, and poor response to current standard-of-care systemic therapies. We previously devised a CTLA4-PD-L1 DNA cancer vaccine (DNA vaccine) and...

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Principais autores:	Yi-Ru Pan, Chiao-En Wu, Wen-Kuan Huang, Ming-Huang Chen, Keng-Hsueh Lan, Chun-Nan Yeh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-10-01
Colecção:	Frontiers in Immunology
Assuntos:	cholangiocarcinoma immune checkpoint proteins protein vaccine immune modulation therapeutic vaccine preventive vaccine
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.982196/full
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