Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hematopoietic diseases when mutated. By generating a novel exon 6 conditional knockout mouse model, we describe an essential role of Setd2 in maintaining the adult hematopoietic stem cells. Loss of Setd2 r...

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Principais autores:	Yile Zhou, Xiaomei Yan, Xiaomin Feng, Jiachen Bu, Yunzhu Dong, Peipei Lin, Yoshihiro Hayashi, Rui Huang, Andre Olsson, Paul R. Andreassen, H. Leighton Grimes, Qian-fei Wang, Tao Cheng, Zhijian Xiao, Jie Jin, Gang Huang
Format:	Artigo
Jezik:	Inglês
Izdano:	Ferrata Storti Foundation 2018-07-01
Serija:	Haematologica
Online dostop:	https://haematologica.org/article/view/8515
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