Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons

Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by the degeneration of spinal cord motoneurons (MNs), progressive muscular atroph...

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Ngā kaituhi matua:	Alba Sansa, Sandra de la Fuente, Joan X. Comella, Ana Garcera, Rosa M. Soler
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2021-07-01
Rangatū:	Neurobiology of Disease
Ngā marau:	Spinal muscular atrophy Motoneurons FAIM Apoptosis Survival motor neuron Akt intracellular pathway
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S0969996121001157
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!