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Zero-shot segmentation using embeddings from a protein language model identifies functional regions in the human proteome.

The biological function of a protein is often determined by its distinct functional units, such as folded domains and intrinsically disordered regions. Identifying and categorizing these protein segments from sequence has been a major focus in computational biology which has enabled the automatic an...

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Autori principali: Ami G Sangster, Cameron Dufault, Haoning Qu, Denise Le, Julie D Forman-Kay, Alan M Moses
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2025-11-01
Serie:PLoS Computational Biology
Accesso online:https://doi.org/10.1371/journal.pcbi.1012929
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