Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction

We previously discovered that the SPC/Fyn/Rho-kinase (ROK) pathway mediates the Ca2+-sensitization of coronary arterial smooth muscle (CASM) contraction leading to vasospasm, a major cause of sudden death. Lately, we have been trying to find and develop more natural edible compounds which can treat...

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Autors principals:	Nan Li, Ying Zhang, Tomoka Morita, Hiroko Kishi, Sei Kobayashi
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-08-01
Col·lecció:	Journal of Pharmacological Sciences
Matèries:	Sphingosylphosphorylcholine (SPC) Fyn Rho-kinase (ROK) activation Tangeretin Citrus flavone
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1347861322000408
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