Uncoupling toxicity from efficacy in donor selection for allogeneic hematopoietic cell transplantation: a retrospective cohort study using double machine learning

Abstract Haploidentical hematopoietic cell transplantation (HCT) offers potent graft-versus-tumor effects but is historically limited by higher non-relapse mortality (NRM) compared to matched unrelated (MUD) or related donors (MRD). To algorithmically decouple the competing risks of NRM and relapse,...

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Autori principali:	Rohtesh S. Mehta, Yosra M. Aljawai, Warren Fingrut, Portia Smallbone, Gabriela Rondon, Amanda Olson, Betul Oran, Partow Kebriaei, Richard E. Champlin, Elizabeth J. Shpall
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-04-01
Serie:	Journal of Hematology & Oncology
Soggetti:	Haploidentical Matched related donor Matched unrelated donor Post-transplantation cyclophosphamide PTCy Non-relapse mortality
Accesso online:	https://doi.org/10.1186/s13045-026-01800-y
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