The CRISPR Spacer Space Is Dominated by Sequences from Species-Specific Mobilomes

ABSTRACT Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems store the memory of past encounters with foreign DNA in unique spacers that are inserted between direct repeats in CRISPR arrays. For only a small fraction of the spacers, homologous...

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Autori principali:	Sergey A. Shmakov, Vassilii Sitnik, Kira S. Makarova, Yuri I. Wolf, Konstantin V. Severinov, Eugene V. Koonin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2017-11-01
Serie:	mBio
Soggetti:	CRISPR-Cas bacteriophages mobilome oligonucleotide composition spacer acquisition
Accesso online:	https://journals.asm.org/doi/10.1128/mBio.01397-17
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