High-Intensity Statins Promote PCSK9 Secretion and aortic valve calcification in patients with severe aortic stenosis: In vitro and clinical evidence

Aortic stenosis (AS) is the most common valvular disease, characterized by progressive fibro-calcific remodeling of the aortic leaflets, leading to increased morbidity and mortality. It is now well known that statins influence the production of proprotein convertase subtilisin/kexin type 9 (PCSK9),...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Veronika A. Myasoedova, Matteo Franchi, Donato De Giorgi, Alice Bonomi, Vincenza Valerio, Sergio Pirola, Niccolò Andreani, Valentina Rusconi, Francesca Bertolini, Ilaria Massaiu, Gianluca Pontone, Paolo Poggio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-05-01
coleção:	Pharmacological Research
Assuntos:	Statin intensity PCSK9 Aortic valve calcification Aortic valve disease hospitalization
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661825001628
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!