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Improving CAR T cell therapy against malignancies through gene knock-down/out strategies: a systematic review

Abstract Background CAR T cells still face numerous obstacles in treating hematologic and solid malignancies. Although gene editing technologies have improved CAR T cell therapy, there are currently no systematic reviews to broadly address preclinical and clinical outcomes of gene-edited CAR T cells...

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Principais autores: Amirali Karimi, Sayedeh-Zahra Kazemi-Harikandei, Sanam Alilou, Dorsa Salabat, Seyed Morteza Pourfaraji, Fatemeh Ojaghi Shirmard, Niloofar Seighali, Saba Maleki, Behnia Akbari, Farshid Noorbakhsh, Jamshid Hadjati, Hamid Reza Mirzaei
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-12-01
coleção:Cancer Cell International
Assuntos:
CAR T cell
Cancer immunology
Gene editing
Knock-out
Knock-down
Acesso em linha:https://doi.org/10.1186/s12935-025-04090-5
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