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Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology

Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Despite this striking clinicopathological co...

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Furkejuvvon:
Váldodahkkit: Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2022-12-01
Ráidu:Acta Neuropathologica Communications
Fáttát:
Semantic dementia
Frontotemporal dementia
Frontotemporal lobar degeneration
TDP-43
Mass spectrometry
Proteomics
Liŋkkat:https://doi.org/10.1186/s40478-022-01499-1
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