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Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

Sodium-glucose co-transporter 2 (SGLT 2) inhibitors are a relatively new antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study aimed to investigate whether SGLT 2 inhibitors have a neuroprotective effect in PD. Twenty-four Wistar rats were randomized into four gr...

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Principais autores: Sanaa Ahmed, Mahmoud M. El-Sayed, Mohamed A. Kandeil, Marwa M. Khalaf
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2022-06-01
Serier:Saudi Pharmaceutical Journal
Fag:
Parkinsonism
Neuroprotection
SGLT-2 inhibitors
Neurodegeneration
Rotenone
α-synuclein
Online adgang:http://www.sciencedirect.com/science/article/pii/S1319016422000640
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