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The Evolution of IL6-IL6R-JAK-STAT Signaling Pathway in Metazoan

Background: The Interleukin-6 (IL6)–Interleukin-6 receptor (IL6R)–Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway plays a crucial role in innate immunity by inducing the production of various immune effectors. However, its stepwise evolutionary assembly a...

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Principais autores: Hong Yu, Renle Chang, Houyou Wang, Muchun He, Jiejie Sun, Linsheng Song
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Biology
Fag:
cytokines
cytokine signaling pathway
metazoan
Mollusca
Porifera
innate immunity
Online adgang:https://www.mdpi.com/2079-7737/15/10/753
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