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Characterization of the mIF4G Domains in the RNA Surveillance Protein Upf2p

Thirty percent of all mutations causing human disease generate mRNAs with premature termination codons (PTCs). Recognition and degradation of these PTC-containing mRNAs is carried out by the mechanism known as nonsense-mediated mRNA decay (NMD). Upf2 is a scaffold protein known to be a central compo...

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Principais autores: Edgardo M. Colón, Luis A. Haddock, Clarivel Lasalde, Qishan Lin, Juan S. Ramírez-Lugo, Carlos I. González
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-12-01
Serier:Current Issues in Molecular Biology
Fag:
<i>Saccharomyces cerevisiae</i>
codon
nonsense
nonsense-mediated mRNA decay
cloning
molecular
Online adgang:https://www.mdpi.com/1467-3045/46/1/17
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