IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration

Summary: Dry age-related macular degeneration (AMD) is a prevalent blinding disorder characterized by loss of retinal pigment epithelium (RPE) cells and resulting central vision impairment. Here, we describe preclinical studies supporting an investigational new drug (IND) application for adult RPE s...

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Egile Nagusiak:	Brigitte L. Arduini, Timothy A. Blenkinsop, Michael Naimark, Susan Borden, Carol Charniga, Melissa Campbell, Natasha Rugenstein, Richard J. Davis, Nazia Alam, Glen Prusky, Amber M. Frye, Francesca Mazzoni, Silvia C. Finnemann, Cuiping Zhao, Patricia Lederman, Janmeet S. Saini, Thomas R. Kiehl, Nicole Renga, Jade A. Kozak, Penny A. Rocchio, Enrique Salero, Nathan C. Boles, Susan K. Goderie, Steven Lotz, Joan E. Adamo, Sharyl Zaccaglino, Khadijah Onanuga, Michael Fiske, Alexandra Capela, Sally Temple, Jeffrey H. Stern
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2026-05-01
Saila:	Cell Reports Medicine
Gaiak:	adult stem cell cell therapy investigational new drug macular degeneration retinal pigment epithelium RPE
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2666379126001965
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