A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens

Abstract Infections with antimicrobial resistant pathogens are a major threat to human health. Inhibitors of the replicative polymerase PolC are a promising novel class of antimicrobials against Gram-positive pathogens, but the structural basis for their activity remains unknown. The first-in-class...

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Hlavní autoři:	Mia Urem, Annemieke H. Friggen, Nina Musch, Michael H. Silverman, Christopher J. Swain, Michael R. Barbachyn, Lawrence I. Mortin, Xiang Yu, Robert J. DeLuccia, Meindert H. Lamers, Wiep Klaas Smits
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-11-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-65324-8
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