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Molecular networking derived from untargeted LC-MS/MS analysis to discover inhibitors of RANKL-induced osteoclastogenesis from Egyptian marine sponge-associated fungi

Abstract In continuous search for RANKL induced osteoclastogenesis inhibitors, twenty-six fungal isolates were obtained from ten Red Sea marine sponges collected from Egypt and the ethyl acetate fractions of their cultures’ methanol extracts were assessed in RAW264 macrophages. Active fractions were...

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Principais autores: Abdelhalim A. Elgahamy, Ahmed H. El-Desoky, Asmaa M. Otify, Ahlam M. El Fishawy, Ahmed A. El-Beih
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-07-01
Serier:Scientific Reports
Fag:
Bisphenols
Osteoclastogenesis
Aspergillus flavus
Metabolomics
Cladosporium
Online adgang:https://doi.org/10.1038/s41598-025-12456-y
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