Somatic genomic profiling reveals clinically relevant heterogeneity in RAS-mutant sporadic medullary thyroid carcinoma

Objective: Sporadic medullary thyroid carcinoma (sMTC) is predominantly driven by somatic RET or RAS mutations, although the molecular basis of disease heterogeneity remains incompletely understood. Our study aims to characterize molecular heterogeneity in sMTC in order to identify pathways that may...

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Podrobná bibliografie

Hlavní autoři:	Edoardo Ruggeri, Simona Censi, Loris Bertazza, Andrea Benetti, Fausto Cortese, Ilaria Piva, Cristina Clausi, Vincenzo Marotta, Francesca Galuppini, Alessandra Giannella, Gianmaria Pennelli, Maurizio Iacobone, Mario Vitale, Giulio Ceolotto, Susi Barollo, Caterina Mian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-05-01
Edice:	Journal of Clinical & Translational Endocrinology
Témata:	NGS somatic panel RAS-mutant tumors Precision medicine strategies T status Biochemical cure
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S221462372600013X
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