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MRDDA: a multi-relational graph neural network for drug–disease association prediction

Abstract Background Drug repositioning offers a promising avenue for accelerating drug development and reducing costs. Recently, computational repositioning approaches have gained attraction for identifying potential drug-disease associations (DDAs). Biological entities such as drugs, genes, protein...

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Principais autores: Congzhou Chen, Yaozheng Zhou, Yinghong Li, Jin Xu, Demin Li, Lingfeng Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Journal of Translational Medicine
Fag:
Drug–disease association
Drug repositioning
Graph neural network
Multiple relations
Online adgang:https://doi.org/10.1186/s12967-025-06783-x
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