In vitro and in vivo anti-inflammatory activity of 17-O-acetylacuminolide through the inhibition of cytokines, NF-κB translocation and IKKβ activity.

BACKGROUND AND PURPOSE: 17-O-acetylacuminolide (AA), a diterpenoid labdane, was isolated for the first time from the plant species Neouvaria foetida. The anti-inflammatory effects of this compound were studied both in vitro and in vivo. EXPERIMENTAL APPROACH: Plant extracts were initially tested aga...

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Autores principales:	Mouna Achoui, David Appleton, Mahmood Ameen Abdulla, Khalijah Awang, Mustafa Ali Mohd, Mohd Rais Mustafa
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2010-01-01
Colección:	PLoS ONE
Acceso en línea:	http://europepmc.org/articles/PMC2995738?pdf=render
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