Loss of Hoxa5 function affects Hox gene expression in different biological contexts

Abstract Hoxa5 plays numerous roles in development, but its downstream molecular effects are mostly unknown. We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and muscu...

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Detalles Bibliográficos

Principais autores:	Béatrice Frenette, Josselin Guéno, Nicolas Houde, Kim Landry-Truchon, Anthony Giguère, Theyjasvi Ashok, Abigail Ryckman, Brian R. Morton, Jennifer H. Mansfield, Lucie Jeannotte
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-12-01
Series:	Scientific Reports
Assuntos:	Hoxa5 Hox expression Hoxa5 mutant mice Chromatin landscape Respiratory system Musculoskeletal system
Acceso en liña:	https://doi.org/10.1038/s41598-024-81867-0
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