Quality by design for mRNA platform purification based on continuous oligo-dT chromatography

Oligo-deoxythymidine (oligo-dT) ligand-based affinity chromatography is a robust method for purifying mRNA drug substances within the manufacturing process of mRNA-based products, including vaccines and therapeutics. However, the conventional batch mode of operation for oligo-dT chromatography has c...

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Detalhes bibliográficos
Main Authors: Jixin Qu, Adithya Nair, George W. Muir, Kate A. Loveday, Zidi Yang, Ehsan Nourafkan, Emma N. Welbourne, Mabrouka Maamra, Mark J. Dickman, Zoltán Kis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-12-01
Colecção:Molecular Therapy: Nucleic Acids
Assuntos:
MT: Delivery Strategies
oligo-dT affinity chromatography
multi-column continuous chromatography process
quality by design
mRNA vaccines
mRNA therapeutics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253124002208
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