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Decoding collagen cues: the interplay of integrins and discoidin domain receptors in health and disease

Abstract The extracellular matrix (ECM) provides critical biochemical and biophysical cues that regulate cell behavior in health and disease. Collagens dominate in abundance and structural importance, shaping tissue-specific ECM signatures that guide cellular behavior. Two major and distinct transme...

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Principais autores: Paola Trono, Ilenia Masi, Flavia Ottavi, Laura Rosanò
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Journal of Biomedical Science
Fag:
Discoidin domain receptor (DDR) 1 and 2
Integrins
Cancer
Collagen
Targeted therapies
Aging
Online adgang:https://doi.org/10.1186/s12929-025-01211-0
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