Charged Tags for the Identification of Oxidative Drug Metabolites Based on Electrochemistry and Mass Spectrometry

Abstract Most of the active pharmaceutical ingredients like Metoprolol are oxidatively metabolized by liver enzymes, such as Cytochrome P450 monooxygenases into oxygenates and therefore hydrophilic products. It is of utmost importance to identify the metabolites and to gain knowledge on their toxic...

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Detalles Bibliográficos

Principais autores:	Alexandra Gutmann, Lars Julian Wesenberg, Nadine Peez, Prof. Dr. Siegfried R. Waldvogel, Prof. Dr. Thorsten Hoffmann
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley-VCH 2020-05-01
Series:	ChemistryOpen
Assuntos:	anodic oxidation charged tags drug metabolites electrochemistry mass spectrometry
Acceso en liña:	https://doi.org/10.1002/open.202000084
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