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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Abstract Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induce...

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Principais autores: Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-01-01
coleção:npj Parkinson's Disease
Acesso em linha:https://doi.org/10.1038/s41531-023-00620-y
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