Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy

Thioredoxin reductases (cytosolic TXNRD1 and mitochondrial TXNRD2) are antioxidant enzymes often overexpressed in tumors, including triple negative breast cancer (TNBC), making them promising targets for cancer therapy. Inhibiting these enzymes may worsen the already elevated oxidative stress in can...

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Detalhes bibliográficos

Principais autores:	Abigail Rullo, Brenna Flowers, Keacha Chang, An Zhang, Valentina Z. Petukhova, Luke Harding, Sammy Y. Aboagye, Maurizio Bocchetta, Wei Qiu, David L. Williams, Francesco Angelucci, Pavel A Petukhov, Irida Kastrati
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-03-01
coleção:	Redox Biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231725004938
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