Dual Hedgehog/GLI1 and PI3K/Akt/mTOR Targeting Possesses Higher Efficacy to Inhibit T-Cell Acute Lymphoblastic Leukemia Growth

While the PI3K/Akt/mTOR pathway is a well-established drug target in T-cell acute lymphoblastic leukemia (T-ALL), the contribution of the Hedgehog (Hh) pathway in T-ALL malignancy remains poorly defined. We investigated the effects of pharmacological inhibition of key signaling nodes in these pathwa...

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Bibliografiska uppgifter

Huvudupphov:	Marica De Chiara, Mariaconcetta Sicurella, Mattia Melloni, Ilaria Conti, Luca Maria Neri
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2025-12-01
Serie:	Cells
Ämnen:	T-cell acute lymphoblastic leukemia (T-ALL) Hedgehog and PI3K/Akt/mTOR signaling synergistic drug combination
Länkar:	https://www.mdpi.com/2073-4409/14/24/1972
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