Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Sensitization of spinal nociceptive circuits plays a crucial role in neuropathic pain. This sensitization depends on new gene expression that is primarily regulated via transcriptional and translational control mechanisms. The relative roles of these mechanisms in regulating gene expression in the c...

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Autori principali:	Kevin C Lister, Calvin Wong, Sonali Uttam, Marc Parisien, Patricia Stecum, Nicole Brown, Weihua Cai, David Ho-Tieng, Mehdi Hooshmandi, Ning Gu, Mehdi Amiri, Francis Beaudry, Seyed Mehdi Jafarnejad, Diana Tavares-Ferreira, Nikhil Nageshwar Inturi, Khadijah Mazhar, Hien T Zhao, Bethany Fitzsimmons, Christos G Gkogkas, Nahum Sonenberg, Theodore J Price, Luda Diatchenko, Yaser Atlasi, Jeffrey S Mogil, Arkady Khoutorsky
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2026-04-01
Serie:	eLife
Soggetti:	mRNA translation neuropathic pain spinal cord DRG neurons gene expression
Accesso online:	https://elifesciences.org/articles/100451
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